According to the authors of recent research from Richmond, California, 'Human adenovirus C (HAdV-C) species are a common cause of respiratory infections and can occasionally produce severe clinical manifestations. A deeper understanding of the variation and evolution in species HAdV-C is especially important since these viruses, including HAdV-C6, are used as gene delivery vectors for human gene therapy and in other biotechnological applications.'
'Here, the full-genome analysis of the prototype HAdV-C6 and a recently identified virus provisionally termed HAdV-C57 are reported. Although the genomes of all species HAdV-C members are very similar to each other, the E3 region, hexon and fiber (ten proteins total) present a wide range of identity values at the amino acid level. Studies of these viruses in comparison to the other three HAdV-C prototypes (1, 2, and 5) comprise a comprehensive analysis of the diversity and conservation within HAdV-C species. HAdV-C6 contains a recombination event within the constant region of the hexon gene,' wrote M.P. Walsh and colleagues (see also Mastadenovirus).
The researchers concluded: 'HAdV-C57 is a recombinant virus with a fiber gene nearly identical to HAdV-C6 and a unique hexon distinguished by its loop 2 motif.'
Walsh and colleagues published their study in the Journal of Clinical Microbiology (Computational Analysis of Two Species C Human Adenoviruses Provides Evidence of a Novel Virus. Journal of Clinical Microbiology, 2011;49(10):3482-3490).
For additional information, contact M.P. Walsh, California Dept. of Public Health, Viral & Rickettsial Diseases Laboratory, Richmond, CA 94804, United States.
Publisher contact information for the Journal of Clinical Microbiology is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA.
Keywords: City:Richmond, State:California, Country:United States, Region:North and Central America, Genetics, Virology, DNA Viruses, Mastadenovirus, Vertebrate Viruses
This article was prepared by Genomics & Genetics Weekly editors from staff and other reports. Copyright 2011, Genomics & Genetics Weekly via NewsRx.com.
